FG-5893

FG-5893

Clinical data
Other names	FG5893
Identifiers
IUPAC name methyl 2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]pyridine-3-carboxylate
CAS Number	150527-23-4
PubChem CID	127728
IUPHAR/BPS	13
ChemSpider	113304
UNII	2QR7EI62WQ
CompTox Dashboard (EPA)	DTXSID50164565
Chemical and physical data
Formula	C27H29F2N3O3
Molar mass	481.544 g·mol−1
3D model (JSmol)	Interactive image
SMILES COC(=O)C1=C(N=CC=C1)N2CCN(CC2)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
InChI InChI=1S/C27H29F2N3O2/c1-34-27(33)25-4-2-14-30-26(25)32-18-16-31(17-19-32)15-3-5-24(20-6-10-22(28)11-7-20)21-8-12-23(29)13-9-21/h2,4,6-14,24H,3,5,15-19H2,1H3 Key:NDCPNKXUTJGQQC-UHFFFAOYSA-N

FG-5893 is a chemical from the diphenylbutylpiperazine class of agents. It is a 5-HT1A agonist and a 5-HT2A antagonist. ^[1]

It is believed to be an anxiolytic agent with potential uses in the treatment of substance abuse disorders particularly alcoholism. ^{[2] [3] [4]}

There is evidence for FG-5893 behaving as a SNDRI: ^[5]

CNS review: ^[6]

See also

• Amperozide
• FG5865

References

1. Myers RD (1994). "New drugs for the treatment of experimental alcoholism". review. Alcohol. 11 (6). Fayetteville, N.Y.: 439–451. doi:10.1016/0741-8329(94)90064-7. PMID   7865140.
2. Albinsson A, Björk A, Svartengren J, Klint T, Andersson G (August 1994). "Preclinical pharmacology of FG5893: a potential anxiolytic drug with high affinity for both 5-HT1A and 5-HT2A receptors". European Journal of Pharmacology. 261 (3): 285–94. doi:10.1016/0014-2999(94)90119-8. PMID   7813550.
3. Lankford MF, Björk AK, Myers RD (1996). "Differential efficacy of serotonergic drugs FG5974, FG5893, and amperozide in reducing alcohol drinking in P rats". Alcohol (Fayetteville, N.Y.). 13 (4): 399–404. doi:10.1016/0741-8329(96)00061-4. PMID   8836330.
4. Long TA, Kalmus GW, Björk A, Myers RD (January 1996). "Alcohol intake in high alcohol drinking (HAD) rats is suppressed by FG5865, a novel 5-HT1A agonist/5-HT2 antagonist". Pharmacology, Biochemistry, and Behavior. 53 (1): 33–40. doi:10.1016/0091-3057(95)00195-6. PMID   8848457.
5. Pettersson, E. (August 1995). "Studies of four novel diphenylbutylpiperazinepyridyl derivatives on release and inhibition of reuptake of dopamine, serotonin and noradrenaline by rat brain in vitro". European Journal of Pharmacology. 282 (1–3): 131–135. doi:10.1016/0014-2999(95)00300-A.
6. Andersson, G., Albinsson, A., Björk, A., Svartengren, J. (December 1996). "FG5893: A Potential New Generation Anxiolytic/Antidepressant Drug with High Affinity for 5-HT 1A and 5-HT 2A Receptors". CNS Drug Reviews. 2 (4): 363–383. doi:10.1111/j.1527-3458.1996.tb00307.x.