Membrane steroid receptor

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Membrane steroid receptors (mSRs), also called extranuclear steroid receptors, are a class of cell surface receptors activated by endogenous steroids that mediate rapid, non-genomic signaling via modulation of intracellular signaling cascades. [1] [2] [3] [4] mSRs are another means besides classical nuclear steroid hormone receptors (SHRs) for steroids to mediate their biological effects. [1] [2] [3] [4] SHRs can produce slow genomic responses or rapid, non-genomic responses in the case of mSRs. [5]

List of membrane steroid receptors

Known groups of mSRs, by ligand, include: [a]

In addition, PDIA3 is a membrane receptor for the secosteroid calcitriol, the activated form of Vitamin D. [8]

References

  1. Semicolons roughly denote structural groups, e.g. G-protein receptors from ion channels.
  1. 1 2 Levin ER (June 2014). "Translating extranuclear steroid receptor signaling to clinical medicine". Hormones & Cancer. 5 (3): 140–145. doi:10.1007/s12672-014-0179-9. PMC   4040225 . PMID   24752388.
  2. 1 2 Hammes SR, Levin ER (December 2011). "Minireview: Recent advances in extranuclear steroid receptor actions". Endocrinology. 152 (12): 4489–4495. doi:10.1210/en.2011-1470. PMC   3858720 . PMID   22028449.
  3. 1 2 Sen A, Prizant H, Hammes SR (August 2011). "Understanding extranuclear (nongenomic) androgen signaling: what a frog oocyte can tell us about human biology". Steroids. 76 (9): 822–828. doi:10.1016/j.steroids.2011.02.016. PMC   4972037 . PMID   21354434.
  4. 1 2 Watson CS (December 1999). "Signaling themes shared between peptide and steroid hormones at the plasma membrane". Science's STKE. 1999 (12): PE1. doi:10.1126/stke.1999.12.pe1. PMC   1317563 . PMID   11865187.
  5. Norman AW, Mizwicki MT, Norman DP (January 2004). "Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model". Nature Reviews. Drug Discovery. 3 (1): 27–41. doi:10.1038/nrd1283. PMID   14708019. S2CID   17487277.
  6. 1 2 3 4 5 6 7 Treviño LS, Gorelick DA (August 2021). "The Interface of Nuclear and Membrane Steroid Signaling". Endocrinology. 162 (8): bqab107. doi:10.1210/endocr/bqab107. PMC   8214340 . PMID   34038515.
  7. Yang Z, Ping YQ, Wang MW, Zhang C, Zhou SH, Xi YT, et al. (January 2025). "Identification, structure, and agonist design of an androgen membrane receptor". Cell. doi:10.1016/j.cell.2025.01.006. PMID   39884271.
  8. Gaucci E, Raimondo D, Grillo C, Cervoni L, Altieri F, Nittari G, et al. (November 2016). "Analysis of the interaction of calcitriol with the disulfide isomerase ERp57". Scientific Reports. 6: 37957. Bibcode:2016NatSR...637957G. doi:10.1038/srep37957. PMC   5126700 . PMID   27897272.