5-HT5B receptor

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5-HT5B receptor is a 5-HT receptor protein and the gene which encodes it. The protein is found in rodents, but not in humans, because stop codons in the gene's coding sequence prevent the gene from expressing a functional protein. [1] It is believed that the function of the 5-HT5B receptor has been replaced in humans by some other subclass of 5-HT receptor. [2] 5-HT5B receptor is a G protein-coupled receptor. [3] 5-HT5B receptor mRNA is expressed primarily in the habenula, hippocampus and inferior olive of rat brains. [4] Known agonists for 5-HT5B include ergotamine and LSD. Known antagonists include methiothepin.

5-HT receptor transmembrane protein

5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand.

Rodent Diverse order of mammals

Rodents are mammals of the order Rodentia, which are characterized by a single pair of continuously growing incisors in each of the upper and lower jaws. About 40% of all mammal species are rodents ; they are found in vast numbers on all continents except Antarctica. They are the most diversified mammalian order and live in a variety of terrestrial habitats, including human-made environments.

Human Common name of Homo sapiens

Humans are the only extant members of the subtribe Hominina. Together with chimpanzees, gorillas, and orangutans, they are part of the family Hominidae. A terrestrial animal, humans are characterized by their erect posture and bipedal locomotion; high manual dexterity and heavy tool use compared to other animals; open-ended and complex language use compared to other animal communications; larger, more complex brains than other animals; and highly advanced and organized societies.

Related Research Articles

The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin) receptors which are G protein-coupled receptors. This ion channel is cation-selective and mediates neuronal depolarization and excitation within the central and peripheral nervous systems.

A melatonin receptor is a G protein-coupled receptor (GPCR) which binds melatonin.

Glucagon-like peptide-1 receptor protein-coding gene in the species Homo sapiens

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Cholecystokinin B receptor protein-coding gene in the species Homo sapiens

The cholecystokinin B receptor also known as CCKBR or CCK2 is a protein that in humans is encoded by the CCKBR gene.

5-HT<sub>2C</sub> receptor protein-coding gene in the species Homo sapiens

The 5-HT2C receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). It is a G protein-coupled receptor (GPCR) that is coupled to Gq/G11 and mediates excitatory neurotransmission. HTR2C denotes the human gene encoding for the receptor, that in humans is located at the X chromosome. As males have one copy of the gene and in females one of the two copies of the gene is repressed, polymorphisms at this receptor can affect the two sexes to differing extent.

5-HT<sub>4</sub> receptor protein-coding gene in the species Homo sapiens

5-Hydroxytryptamine receptor 4 is a protein that in humans is encoded by the HTR4 gene.

Bradykinin receptor B1 protein-coding gene in the species Homo sapiens

Bradykinin receptor B1 (B1) is a G-protein coupled receptor encoded by the BDKRB1 gene in humans. Its principal ligand is bradykinin, a 9 amino acid peptide generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The B1 receptor is one of two of G protein-coupled receptors that have been found which bind bradykinin and mediate responses to these pathophysiologic conditions.

5-HT<sub>1A</sub> receptor protein-coding gene in the species Homo sapiens

The serotonin 1A receptor is a subtype of serotonin receptor that binds the neurotransmitter serotonin. It is a G protein-coupled receptor (GPCR), coupled to the Gi protein, that mediates inhibitory neurotransmission. The serotonin 1A receptor is encoded by the HTR1A gene.

5-HT<sub>1B</sub> receptor protein-coding gene in the species Homo sapiens

5-hydroxytryptamine receptor 1B also known as the 5-HT1B receptor is a protein that in humans is encoded by the HTR1B gene. The 5-HT1B receptor is a 5-HT receptor subtype.

5-HT<sub>1D</sub> receptor protein-coding gene in the species Homo sapiens

5-hydroxytryptamine (serotonin) receptor 1D, also known as HTR1D, is a 5-HT receptor, but also denotes the human gene encoding it. 5-HT1D acts on the central nervous system, and affects locomotion and anxiety. It also induces vascular vasoconstriction in the brain.

5-HT<sub>1E</sub> receptor protein-coding gene in the species Homo sapiens

5-hydroxytryptamine (serotonin) 1E receptor (5-HT1E) is a highly expressed human G-protein coupled receptor that belongs to the 5-HT1 receptor family. The human gene is denoted as HTR1E.

5-HT<sub>1F</sub> receptor protein-coding gene in the species Homo sapiens

5-hydroxytryptamine (serotonin) receptor 1F, also known as HTR1F is a 5-HT1 receptor protein and also denotes the human gene encoding it.

5-HT<sub>5A</sub> receptor protein-coding gene in the species Homo sapiens

5-Hydroxytryptamine (serotonin) receptor 5A, also known as HTR5A, is a protein that in humans is encoded by the HTR5A gene.

Somatostatin receptor 3 protein-coding gene in the species Homo sapiens

Shekel Somatostatin receptor type 3 is a protein that in humans is encoded by the SSTR3 gene.

5-HT<sub>7</sub> receptor protein-coding gene in the species Homo sapiens

The 5-HT7 receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) The 5-HT7 receptor is coupled to Gs (stimulates the production of the intracellular signaling molecule cAMP) and is expressed in a variety of human tissues, particularly in the brain, the gastrointestinal tract, and in various blood vessels. This receptor has been a drug development target for the treatment of several clinical disorders. The 5-HT7 receptor is encoded by the HTR7 gene, which in humans is transcribed into 3 different splice variants.

Neurotensin receptor 1 protein-coding gene in the species Homo sapiens

Neurotensin receptor type 1 is a protein that in humans is encoded by the NTSR1 gene. For a crystal structure of NTS1, see pdb code 4GRV.

CHRNA3 protein-coding gene in the species Homo sapiens

Neuronal acetylcholine receptor subunit alpha-3, also known as nAChRα3, is a protein that in humans is encoded by the CHRNA3 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

CHRNB3 protein-coding gene in the species Homo sapiens

Neuronal acetylcholine receptor subunit beta-3 is a protein that in humans is encoded by the CHRNB3 gene.

Naphthylpiperazine chemical compound

1-(1-Naphthyl)piperazine (1-NP) is a drug which is a phenylpiperazine derivative. It acts as a non-selective, mixed serotonergic agent, exerting partial agonism at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F receptors, while antagonizing the 5-HT2A, 5-HT2B, and 5-HT2C receptors. It has also been shown to possess high affinity for the 5-HT3, 5-HT5A, 5-HT6, and 5-HT7 receptors, and may bind to 5-HT4 and the SERT as well. In animals it produces effects including hyperphagia, hyperactivity, and anxiolysis, of which are all likely mediated predominantly or fully by blockade of the 5-HT2C receptor.

References

  1. ↑ Grailhe, R; Grabtree, GW; Hen, R (2001-04-27). "Human 5-HT(5) receptors: the 5-HT(5A) receptor is functional but the 5-HT(5B) receptor was lost during mammalian evolution". European Journal of Pharmacology . 418 (3): 157–67. doi:10.1016/S0014-2999(01)00933-5. PMID   11343685.
  2. ↑ Roth, Bryan L., ed. (2006). The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics. The receptors (1st ed.). Humana Press. p. 25. ISBN   978-1-58829-568-2 . Retrieved 2009-11-08.
  3. ↑ Wisden, William; Parker, Eric M.; Mahle, Cathy D.; Grisel, Darcy A.; Nowak, Henry P.; Yocca, Frank D.; Felder, Christian C.; Seeburg, Peter H.; Voigt, Mark M. (1993-10-25). "Cloning and characterization of the rat 5-HT5B receptor: Evidence that the 5-HT5B receptor couples to a G protein in mammalian cell membranes" (PDF). FEBS Letters . 333 (1): 25–31. doi:10.1016/0014-5793(93)80368-5. PMID   8224165 . Retrieved 2009-11-02.
  4. ↑ Kinsey, AM; Wainwright, A; Heavens, R; Sirinathsinghji, DJ; Oliver, KR (2001-03-31). "Distribution of 5-ht(5A), 5-ht(5B), 5-ht(6) and 5-HT(7) receptor mRNAs in the rat brain". Molecular Brain Research. 88 (1–2): 194–8. doi:10.1016/S0169-328X(01)00034-1. PMID   11295248.


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