CCAAT/enhancer binding protein zeta

CEBPZ
Identifiers
Aliases	CEBPZ , CBF, CBF2, HSP-CBF, NOC1, CCAAT/enhancer binding protein zeta, CCAAT enhancer binding protein zeta
External IDs	OMIM: 612828; MGI: 109386; HomoloGene: 4210; GeneCards: CEBPZ; OMA:CEBPZ - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p22.2 Start 37,201,612 bp [1] End 37,231,596 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 E3 Start 79,226,435 bp [2] End 79,244,495 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon tendon of biceps brachii ventricular zone internal globus pallidus left testis gastrocnemius muscle right testis testicle epithelium of colon pericardium Top expressed in otic placode basilar part of occipital bone saccule otic vesicle tail of embryo genital tubercle maxillary prominence lacrimal gland mandibular prominence Ileal epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific RNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated positive regulation of transcription by RNA polymerase II ribosome biogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10153 12607 Ensembl ENSG00000115816 ENSMUSG00000024081 UniProt Q03701 P53569 RefSeq (mRNA) NM_005760 NM_001024806 NM_009882 RefSeq (protein) NP_005751 NP_001019977 Location (UCSC) Chr 2: 37.2 – 37.23 Mb Chr 17: 79.23 – 79.24 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CCAAT/enhancer-binding protein zeta is a protein that in humans is encoded by the CEBPZ gene. ^{[5] [6] [7]}

Interactions

CCAAT/enhancer binding protein zeta has been shown to interact with:

• NFYB, ^[8]
• P53, ^[6]
• P73 ^[9]

See also

• Ccaat-enhancer-binding proteins

References

1. GRCh38: Ensembl release 89: ENSG00000115816 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024081 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lum LS, Sultzman LA, Kaufman RJ, Linzer DI, Wu BJ (Jan 1991). "A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter". Mol Cell Biol. 10 (12): 6709–17. doi:10.1128/mcb.10.12.6709. PMC   362949 . PMID   2247079.
6. Uramoto H, Izumi H, Nagatani G, Ohmori H, Nagasue N, Ise T, Yoshida T, Yasumoto K, Kohno K (Apr 2003). "Physical interaction of tumour suppressor p53/p73 with CCAAT-binding transcription factor 2 (CTF2) and differential regulation of human high-mobility group 1 (HMG1) gene expression". Biochem J. 371 (Pt 2): 301–10. doi:10.1042/BJ20021646. PMC   1223307 . PMID   12534345.
7. "Entrez Gene: CEBPZ CCAAT/enhancer binding protein zeta".
8. Imbriano C, Bolognese F, Gurtner A, Piaggio G, Mantovani R (Jul 2001). "HSP-CBF is an NF-Y-dependent coactivator of the heat shock promoters CCAAT boxes". J. Biol. Chem. 276 (28): 26332–9. doi: 10.1074/jbc.M101553200 . hdl: 11380/303761 . PMID   11306579.
9. Uramoto H, Izumi H, Nagatani G, Ohmori H, Nagasue N, Ise T, Yoshida T, Yasumoto K, Kohno K (Apr 2003). "Physical interaction of tumour suppressor p53/p73 with CCAAT-binding transcription factor 2 (CTF2) and differential regulation of human high-mobility group 1 (HMG1) gene expression". Biochem. J. 371 (Pt 2): 301–10. doi:10.1042/BJ20021646. PMC   1223307 . PMID   12534345.

Further reading

• Hoeppner MA, Gilbert DJ, Copeland NG, Jenkins NA, Linzer DI, Wu B (1996). "Cloning and characterization of mouse CCAAT binding factor". Nucleic Acids Res. 24 (6): 1091–8. doi:10.1093/nar/24.6.1091. PMC   145757 . PMID   8604343.
• Imbriano C, Bolognese F, Gurtner A, Piaggio G, Mantovani R (2001). "HSP-CBF is an NF-Y-dependent coactivator of the heat shock promoters CCAAT boxes". J. Biol. Chem. 276 (28): 26332–9. doi: 10.1074/jbc.M101553200 . hdl: 11380/303761 . PMID   11306579.
• Iouzalen N, Andreae S, Hannier S, Triebel F (2001). "LAP, a lymphocyte activation gene-3 (LAG-3)-associated protein that binds to a repeated EP motif in the intracellular region of LAG-3, may participate in the down-regulation of the CD3/TCR activation pathway". Eur. J. Immunol. 31 (10): 2885–91. doi:10.1002/1521-4141(2001010)31:10<2885::AID-IMMU2885>3.0.CO;2-2. PMID   11592063. S2CID   26417417.
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Milkereit P, Strauss D, Bassler J, Gadal O, Kühn H, Schütz S, Gas N, Lechner J, Hurt E, Tschochner H (2003). "A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits". J. Biol. Chem. 278 (6): 4072–81. doi: 10.1074/jbc.M208898200 . PMID   12446671.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.

External links

• CEBPz+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• CEBPZ human gene location in the UCSC Genome Browser .
• CEBPZ human gene details in the UCSC Genome Browser .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.