MLL4

Last updated
KMT2B
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases KMT2B , HRX2, MLL1B, MLL2, MLL4, TRX2, WBP-7, WBP7, CXXC10, lysine methyltransferase 2B, DYT28
External IDs OMIM: 606834 MGI: 109565 HomoloGene: 22838 GeneCards: KMT2B
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014727

NM_001290573
NM_029274

RefSeq (protein)

NP_055542

NP_001277502
NP_083550

Location (UCSC) Chr 19: 35.72 – 35.74 Mb Chr 7: 30.27 – 30.29 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myeloid/lymphoid or mixed-lineage leukemia 4, also known as MLL4, is a human gene. [5]

Contents

This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known. [5]

Related Research Articles

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Histone-lysine N-methyltransferase 2A also known as acute lymphoblastic leukemia 1 (ALL-1), myeloid/lymphoid or mixed-lineage leukemia1 (MLL1), or zinc finger protein HRX (HRX) is an enzyme that in humans is encoded by the KMT2A gene.

<span class="mw-page-title-main">Homeobox A10</span> Protein-coding gene in humans

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Factor interacting with PAPOLA and CPSF1 is a protein that in humans is encoded by the FIP1L1 gene. A medically important aspect of the FIP1L1 gene is its fusion with other genes to form fusion genes which cause clonal hypereosinophilia and leukemic diseases in humans.

<span class="mw-page-title-main">AFF1</span> Protein-coding gene in the species Homo sapiens

AF4/FMR2 family member 1 is a protein that in humans is encoded by the AFF1 gene. At its same location was a record for a separate PBM1 gene, which has since been withdrawn and considered an alias. It was previously known as AF4.

<span class="mw-page-title-main">HOXB3</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene.

<span class="mw-page-title-main">KMT2C</span> Protein-coding gene in the species Homo sapiens

Lysine N-methyltransferase 2C (KMT2C) also known as myeloid/lymphoid or mixed-lineage leukemia protein 3 (MLL3) is an enzyme that in humans is encoded by the KMT2C gene.

<span class="mw-page-title-main">WDR5</span> Protein-coding gene in the species Homo sapiens

WD repeat-containing protein 5 is a protein that in humans is encoded by the WDR5 gene.

<span class="mw-page-title-main">CD200</span>

OX-2 membrane glycoprotein, also named CD200 is a human protein encoded by the CD200 gene.

<span class="mw-page-title-main">PICALM</span>

Phosphatidylinositol binding clathrin assembly protein, also known as PICALM, is a protein which in humans is encoded by the PICALM gene.

<span class="mw-page-title-main">CXXC1</span>

CpG-binding protein (CGBP) also known as CXXC-type zinc finger protein 1 (CXXC1) or PHD finger and CXXC domain-containing protein 1 (PCCX1) is a protein that in humans is encoded by the CXXC1 gene.

<span class="mw-page-title-main">MLLT3</span> Protein-coding gene in the species Homo sapiens

Protein AF-9 is a protein that in humans is encoded by the MLLT3 gene.

<span class="mw-page-title-main">LILRB3</span> Protein-coding gene in the species Homo sapiens

Leukocyte immunoglobulin-like receptor subfamily B member 3 is a protein that in humans is encoded by the LILRB3 gene.

<span class="mw-page-title-main">KMT2D</span> Protein-coding gene in the species Homo sapiens

Histone-lysine N-methyltransferase 2D (KMT2D), also known as MLL4 and sometimes MLL2 in humans and Mll4 in mice, is a major mammalian histone H3 lysine 4 (H3K4) mono-methyltransferase. It is part of a family of six Set1-like H3K4 methyltransferases that also contains KMT2A, KMT2B, KMT2C, KMT2F, and KMT2G.

<span class="mw-page-title-main">MLLT1</span> Protein-coding gene in the species Homo sapiens

Protein ENL is a protein that in humans is encoded by the MLLT1 gene.

<span class="mw-page-title-main">PBX3</span> Protein found in humans

Pre-B-cell leukemia transcription factor 3 is a protein that in humans is encoded by the PBX3 gene.

<span class="mw-page-title-main">LILRA2</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">ASH1L</span>

ASH1L is a histone-lysine N-methyltransferase enzyme encoded by the ASH1L gene located at chromosomal band 1q22. ASH1L is the human homolog of Drosophila Ash1.

<span class="mw-page-title-main">Tet methylcytosine dioxygenase 2</span> Human gene

Tet methylcytosine dioxygenase 2 (TET2) is a human gene. It resides at chromosome 4q24, in a region showing recurrent microdeletions and copy-neutral loss of heterozygosity (CN-LOH) in patients with diverse myeloid malignancies.

<span class="mw-page-title-main">KMT2E</span>

Lysine methyltransferase 2E is a protein that in humans is encoded by the KMT2E gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000272333 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006307 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: MLL4 myeloid/lymphoid or mixed-lineage leukemia 4".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.