PEG3

PEG3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BHX
Identifiers
Aliases	PEG3 , PW1, ZKSCAN22, ZNF904, ZSCAN24, paternally expressed 3
External IDs	OMIM: 601483 MGI: 104748 HomoloGene: 31363 GeneCards: PEG3
Gene location (Human)
Chr.	Chromosome 19 (human)
End	56,840,728 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	6,730,431 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; superior vestibular nucleus; ; Brodmann area 23; ; pons; ; middle temporal gyrus; ; ventral tegmental area; ; external globus pallidus; ; cerebellar vermis; ; parietal lobe; ; entorhinal cortex;
	Top expressed in
	belly cord; ; condyle; ; medullary collecting duct; ; pituitary gland; ; substantia nigra; ; ventromedial nucleus; ; fossa; ; dorsomedial hypothalamic nucleus; ; abdominal wall; ; dermis;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity ; metal ion binding ; nucleic acid binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	cytoplasm ; nucleus ; autophagosome ;
Biological process	apoptotic process ; regulation of gene expression ; regulation of transcription, DNA-templated ; negative regulation of transcription by RNA polymerase II ; positive regulation of transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	5178
	18616
	ENSG00000198300
	ENSMUSG00000002265
	Q9GZU2
	Q3URU2
	NM_006210 ; NM_001146184 ; NM_001146185 ; NM_001146186 ; NM_001146187 Contents Interactions ; References ; Further reading ;
	NM_008817
	NP_001139656 ; NP_001139657 ; NP_001139658 ; NP_001139659 ; NP_006201
	NP_032843
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 19, 2023

Paternally-expressed gene 3 protein is a protein that in humans is encoded by the PEG3 gene.^[5]^[6] PEG3 is an imprinted gene expressed exclusively from the paternal allele and plays important roles in controlling fetal growth rates and nurturing behaviors as has potential roles in mammalian reproduction.^[7] PEG3 is a transcription factor that binds to DNA [11-13] via the sequence motif AGTnnCnnnTGGCT, which it binds to using multiple Kruppel-like factors. It also regulate the expression of Pgm2l1 through the binding of the motif.^[8]

Interactions

PEG3 has been shown to interact with SIAH2 ^[9] and SIAH1.^[9] kjh-5oil2-*m jhac-*n.,myr0.

Related Research Articles

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Frizzled-5(Fz-5) is a protein that in humans is encoded by the FZD5 gene.

Frizzled-7(Fd-7) is a protein that in humans is encoded by the FZD7 gene.

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Mesoderm-specific transcript homolog protein is a protein that in humans is encoded by the MEST gene.

Retrotransposon-derived protein PEG10 is a protein that in humans is encoded by the PEG10 gene.

Kinesin-like protein KIF22 is a protein that in humans is encoded by the KIF22 gene.

Cyclic AMP-responsive element-binding protein 3 is a protein that in humans is encoded by the CREB3 gene.

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Type I inositol-3,4-bisphosphate 4-phosphatase is an enzyme that in humans is encoded by the INPP4A gene.

SET domain containing 2 is an enzyme that in humans is encoded by the SETD2 gene.

39S ribosomal protein L41, mitochondrial is a protein that in humans is encoded by the MRPL41 gene.

Protein Jade-3 is a protein that in humans is encoded by the PHF16 gene.

Rex1 (Zfp-42) is a known marker of pluripotency, and is usually found in undifferentiated embryonic stem cells. In addition to being a marker for pluripotency, its regulation is also critical in maintaining a pluripotent state. As the cells begin to differentiate, Rex1 is severely and abruptly downregulated.

Zinc finger protein 264 is a protein that in humans is encoded by the ZNF264 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198300 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002265 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kim J, Ashworth L, Branscomb E, Stubbs L (August 1997). "The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4". Genome Res. 7 (5): 532–40. doi:10.1101/gr.7.5.532. PMC 310658 . PMID 9149948.
↑ "Entrez Gene: PEG3 paternally expressed 3".
↑ Michelle M. Thiaville; Jennifer M. Huang; Hana Kim; Muhammad B. Ekram; Arundhati Bakshi; Tae-Young Roh; Joomyeong Kim (December 31, 2013). "Peg3 Mutational Effects on Reproduction and Placenta-Specific Gene Families". PLOS ONE. 8 (12): e83359. Bibcode:2013PLoSO...883359K. doi: 10.1371/journal.pone.0083359 . PMC 3877027 . PMID 24391757.
↑ Thiaville MM, Huang JM, Kim H, Ekram MB, Roh TY, Kim J (January 2013). "DNA-binding motif and target genes of the imprinted transcription factor PEG3". Gene. 512 (2): 314–320. doi:10.1016/j.gene.2012.10.005. PMC 3513644 . PMID 23078764.
1 2 Relaix, F; Wei X j; Li W; Pan J; Lin Y; Bowtell D D; Sassoon D A; Wu X (February 2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 97 (5): 2105–10. Bibcode:2000PNAS...97.2105R. doi: 10.1073/pnas.040378897 . ISSN 0027-8424. PMC 15761 . PMID 10681424.

Relaix F, Wei XJ, Wu X, Sassoon DA (1998). "Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway". Nat. Genet. 18 (3): 287–91. doi:10.1038/ng0398-287. PMID 9500555. S2CID 1235332.
Relaix F, Wei X, Li W, et al. (2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis". Proc. Natl. Acad. Sci. U.S.A. 97 (5): 2105–10. Bibcode:2000PNAS...97.2105R. doi: 10.1073/pnas.040378897 . PMC 15761 . PMID 10681424.
Kim J, Bergmann A, Stubbs L (2000). "Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3)". Genomics. 64 (1): 114–8. doi:10.1006/geno.1999.6112. PMID 10708526.
Kohda T, Asai A, Kuroiwa Y, et al. (2001). "Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line". Genes Cells. 6 (3): 237–47. doi: 10.1046/j.1365-2443.2001.00412.x . PMID 11260267. S2CID 43806250.
Hiby SE, Lough M, Keverne EB, et al. (2001). "Paternal monoallelic expression of PEG3 in the human placenta". Hum. Mol. Genet. 10 (10): 1093–100. doi:10.1093/hmg/10.10.1093. PMID 11331620.
Yarden RI, Brody LC (2002). "Identification of proteins that interact with BRCA1 by Far-Western library screening". J. Cell. Biochem. 83 (4): 521–31. doi:10.1002/jcb.1257. PMID 11746496. S2CID 29703139.
Johnson MD, Wu X, Aithmitti N, Morrison RS (2002). "Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death". J. Biol. Chem. 277 (25): 23000–7. doi: 10.1074/jbc.M201907200 . PMID 11943780.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Mirey G, Chartrain I, Froment C, et al. (2006). "CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis". Cell Cycle. 4 (6): 806–11. doi: 10.4161/cc.4.6.1716 . PMID 15908796.
Dowdy SC, Gostout BS, Shridhar V, et al. (2005). "Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines". Gynecol. Oncol. 99 (1): 126–34. doi:10.1016/j.ygyno.2005.05.036. PMID 16023706.
Chartrain I, Couturier A, Tassan JP (2006). "Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells". Biol. Cell. 98 (4): 253–63. doi: 10.1042/BC20050041 . PMID 16159311. S2CID 45211094.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID 16713569. S2CID 13709685.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198300 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002265 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9149948-5] Kim J, Ashworth L, Branscomb E, Stubbs L (August 1997). "The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4". Genome Res. 7 (5): 532–40. doi:10.1101/gr.7.5.532. PMC 310658 . PMID 9149948.

[entrez-6] "Entrez Gene: PEG3 paternally expressed 3".

[7] Michelle M. Thiaville; Jennifer M. Huang; Hana Kim; Muhammad B. Ekram; Arundhati Bakshi; Tae-Young Roh; Joomyeong Kim (December 31, 2013). "Peg3 Mutational Effects on Reproduction and Placenta-Specific Gene Families". PLOS ONE. 8 (12): e83359. Bibcode:2013PLoSO...883359K. doi: 10.1371/journal.pone.0083359 . PMC 3877027 . PMID 24391757.

[pmid23078764-8] Thiaville MM, Huang JM, Kim H, Ekram MB, Roh TY, Kim J (January 2013). "DNA-binding motif and target genes of the imprinted transcription factor PEG3". Gene. 512 (2): 314–320. doi:10.1016/j.gene.2012.10.005. PMC 3513644 . PMID 23078764.

[pmid10681424-9] 1 2 Relaix, F; Wei X j; Li W; Pan J; Lin Y; Bowtell D D; Sassoon D A; Wu X (February 2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 97 (5): 2105–10. Bibcode:2000PNAS...97.2105R. doi: 10.1073/pnas.040378897 . ISSN 0027-8424. PMC 15761 . PMID 10681424.

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PEG3

Contents

Interactions

Related Research Articles

References

Further reading