PEG3

PEG3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BHX
Identifiers
Aliases	PEG3 , PW1, ZKSCAN22, ZNF904, ZSCAN24, paternally expressed 3
External IDs	OMIM: 601483; MGI: 104748; HomoloGene: 31363; GeneCards: PEG3; OMA:PEG3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.43 Start 56,810,077 bp [1] End 56,840,728 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 A1|7 3.89 cM Start 6,703,892 bp [2] End 6,730,431 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell superior vestibular nucleus lateral nuclear group of thalamus Brodmann area 23 pons Epithelium of choroid plexus middle temporal gyrus ventral tegmental area external globus pallidus dorsal motor nucleus of vagus nerve Top expressed in umbilical cord condyle medullary collecting duct pituitary gland substantia nigra ventromedial nucleus fossa human fetus dorsomedial hypothalamic nucleus abdominal wall More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleus autophagosome Biological process apoptotic process regulation of gene expression regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5178 18616 Ensembl ENSG00000198300 ENSMUSG00000002265 UniProt Q9GZU2 Q3URU2 RefSeq (mRNA) NM_006210 NM_001146184 NM_001146185 NM_001146186 NM_001146187 NM_008817 RefSeq (protein) NP_001139656 NP_001139657 NP_001139658 NP_001139659 NP_006201 NP_032843 Location (UCSC) Chr 19: 56.81 – 56.84 Mb Chr 7: 6.7 – 6.73 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Paternally-expressed gene 3 protein is a protein that in humans is encoded by the PEG3 gene. ^{[5] [6]} PEG3 is an imprinted gene expressed exclusively from the paternal allele and plays important roles in controlling fetal growth rates and nurturing behaviors as has potential roles in mammalian reproduction. ^[7] PEG3 is a transcription factor that binds to DNA [11-13] via the sequence motif AGTnnCnnnTGGCT, which it binds to using multiple Kruppel-like factors. It also regulate the expression of Pgm2l1 through the binding of the motif. ^[8]

Interactions

PEG3 has been shown to interact with SIAH2 ^[9] and SIAH1. ^[9] kjh-5oil2-*m jhac-*n.,myr0.

References

1. GRCh38: Ensembl release 89: ENSG00000198300 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002265 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kim J, Ashworth L, Branscomb E, Stubbs L (August 1997). "The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4". Genome Res. 7 (5): 532–40. doi:10.1101/gr.7.5.532. PMC   310658 . PMID   9149948.
6. "Entrez Gene: PEG3 paternally expressed 3".
7. Michelle M. Thiaville; Jennifer M. Huang; Hana Kim; Muhammad B. Ekram; Arundhati Bakshi; Tae-Young Roh; Joomyeong Kim (December 31, 2013). "Peg3 Mutational Effects on Reproduction and Placenta-Specific Gene Families". PLOS ONE. 8 (12) e83359. Bibcode:2013PLoSO...883359K. doi: 10.1371/journal.pone.0083359 . PMC   3877027 . PMID   24391757.
8. Thiaville MM, Huang JM, Kim H, Ekram MB, Roh TY, Kim J (January 2013). "DNA-binding motif and target genes of the imprinted transcription factor PEG3". Gene. 512 (2): 314–320. doi:10.1016/j.gene.2012.10.005. PMC   3513644 . PMID   23078764.
9. Relaix, F; Wei X j; Li W; Pan J; Lin Y; Bowtell D D; Sassoon D A; Wu X (February 2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis". Proc. Natl. Acad. Sci. U.S.A. 97 (5). UNITED STATES: 2105–10. Bibcode:2000PNAS...97.2105R. doi: 10.1073/pnas.040378897 . ISSN   0027-8424. PMC   15761 . PMID   10681424.

Further reading

• Relaix F, Wei XJ, Wu X, Sassoon DA (1998). "Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway". Nat. Genet. 18 (3): 287–91. doi:10.1038/ng0398-287. PMID   9500555. S2CID   1235332.
• Relaix F, Wei X, Li W, et al. (2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis". Proc. Natl. Acad. Sci. U.S.A. 97 (5): 2105–10. Bibcode:2000PNAS...97.2105R. doi: 10.1073/pnas.040378897 . PMC   15761 . PMID   10681424.
• Kim J, Bergmann A, Stubbs L (2000). "Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3)". Genomics. 64 (1): 114–8. doi:10.1006/geno.1999.6112. PMID   10708526.
• Kohda T, Asai A, Kuroiwa Y, et al. (2001). "Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line". Genes Cells. 6 (3): 237–47. doi: 10.1046/j.1365-2443.2001.00412.x . PMID   11260267. S2CID   43806250.
• Hiby SE, Lough M, Keverne EB, et al. (2001). "Paternal monoallelic expression of PEG3 in the human placenta". Hum. Mol. Genet. 10 (10): 1093–100. doi:10.1093/hmg/10.10.1093. PMID   11331620.
• Yarden RI, Brody LC (2002). "Identification of proteins that interact with BRCA1 by Far-Western library screening". J. Cell. Biochem. 83 (4): 521–31. doi:10.1002/jcb.1257. PMID   11746496. S2CID   29703139.
• Johnson MD, Wu X, Aithmitti N, Morrison RS (2002). "Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death". J. Biol. Chem. 277 (25): 23000–7. doi: 10.1074/jbc.M201907200 . PMID   11943780.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Mirey G, Chartrain I, Froment C, et al. (2006). "CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis". Cell Cycle. 4 (6): 806–11. doi: 10.4161/cc.4.6.1716 . PMID   15908796.
• Dowdy SC, Gostout BS, Shridhar V, et al. (2005). "Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines". Gynecol. Oncol. 99 (1): 126–34. doi:10.1016/j.ygyno.2005.05.036. PMID   16023706.
• Chartrain I, Couturier A, Tassan JP (2006). "Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells". Biol. Cell. 98 (4): 253–63. doi: 10.1042/BC20050041 . PMID   16159311. S2CID   45211094.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.