Basic leucine zipper transcription factor, ATF-like, also known as BATF, is a protein which in humans is encoded by the BATF gene. [5] [6] [7]
Basic leucine zipper transcription factor, ATF-like, also known as BATF, is a protein which in humans is encoded by the BATF gene. [5] [6] [7]
The protein encoded by this gene is a nuclear basic leucine zipper (bZIP) protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [7]
Mice without the BATF gene (BATF knockout mice) lacked a type of inflammatory immune cell (Th17) and were resistant to conditions that normally induces an autoimmune condition similar to multiple sclerosis. [8]
Transcription factor JunD is a protein that in humans is encoded by the JUND gene.
Transcription factor jun-B is a protein that in humans is encoded by the JUNB gene. Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.
Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.
Activating transcription factor 4 , also known as ATF4, is a protein that in humans is encoded by the ATF4 gene.
Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene and is involved in the unfolded protein response.
Activating transcription factor 2, also known as ATF2, is a protein that, in humans, is encoded by the ATF2 gene.
Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene.
Sterile alpha motif and leucine zipper containing kinase AZK, also known as ZAK, is a human gene.
Elongin A is a protein that in humans is encoded by the ELOA gene.
Mitogen-activated protein kinase 12 is an enzyme that in humans is encoded by the MAP3K12 gene.
TSC22 domain family protein 1 is a protein that in humans is encoded by the TSC22D1 gene.
Activating transcription factor 5, also known as ATF5, is a protein that, in humans, is encoded by the ATF5 gene.
Transcription cofactor HES-6 is a protein that in humans is encoded by the HES6 gene.
Interferon-induced 35 kDa protein is a protein that in humans is encoded by the IFI35 gene.
Myeloid zinc finger 1 is a protein that in humans is encoded by the MZF1 gene.
Cytohesin-interacting protein is a protein that in humans is encoded by the CYTIP gene.
Serine/threonine-protein kinase SIK1 is an enzyme that in humans is encoded by the SIK1 gene.
Tumor necrosis factor receptor superfamily member 19L is a protein that in humans is encoded by the RELT gene.
The Basic Leucine Zipper Domain is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper that is required to hold together (dimerize) two DNA binding regions. The DNA binding region comprises a number of basic amino acids such as arginine and lysine. Proteins containing this domain are transcription factors.
Prolyl 4-hydroxylase, transmembrane is a protein that in humans is encoded by the P4HTM gene.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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