KMT2C | |||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||
Aliases | KMT2C , HALR, MLL3, lysine methyltransferase 2C, KLEFS2 | ||||||||||||||||||||||||
External IDs | OMIM: 606833 MGI: 2444959 HomoloGene: 46480 GeneCards: KMT2C | ||||||||||||||||||||||||
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Orthologs | |||||||||||||||||||||||||
Species | Human | Mouse | |||||||||||||||||||||||
Entrez | |||||||||||||||||||||||||
Ensembl |
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RefSeq (mRNA) | |||||||||||||||||||||||||
RefSeq (protein) |
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Location (UCSC) | Chr 7: 152.13 – 152.44 Mb | n/a | |||||||||||||||||||||||
PubMed search | [2] | [3] | |||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||
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Lysine N-methyltransferase 2C (KMT2C) also known as myeloid/lymphoid or mixed-lineage leukemia protein 3 (MLL3) is an enzyme that in humans is encoded by the KMT2C gene. [4] [5]
This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT-hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [5]
MLL3 has been shown to interact with NCOA6 [6] and RBBP5. [6]
Lymphoid enhancer-binding factor 1 (LEF1) is a protein that in humans is encoded by the LEF1 gene.
Histone-lysine N-methyltransferase 2A also known as acute lymphoblastic leukemia 1 (ALL-1), myeloid/lymphoid or mixed-lineage leukemia1 (MLL1), or zinc finger protein HRX (HRX) is an enzyme that in humans is encoded by the KMT2A gene.
Homeobox protein Meis1 is a protein that in humans is encoded by the MEIS1 gene.
40S ribosomal protein S3 is a protein that in humans is encoded by the RPS3 gene.
Tax1-binding protein 1 is a protein that in humans is encoded by the TAX1BP1 gene.
SAP domain-containing ribonucleoprotein is a protein that in humans is encoded by the SARNP gene.
B-cell lymphoma/leukemia 11A is a protein that in humans is encoded by the BCL11A gene.
Phosphatidylinositol binding clathrin assembly protein, also known as PICALM, is a protein which in humans is encoded by the PICALM gene.
Protein AF-9 is a protein that in humans is encoded by the MLLT3 gene.
Histone-lysine N-methyltransferase 2D (KMT2D), also known as MLL4 and sometimes MLL2 in humans and Mll4 in mice, is a major mammalian histone H3 lysine 4 (H3K4) mono-methyltransferase. It is part of a family of six Set1-like H3K4 methyltransferases that also contains KMT2A, KMT2B, KMT2C, KMT2F, and KMT2G.
Set1/Ash2 histone methyltransferase complex subunit ASH2 is an enzyme that in humans is encoded by the ASH2L gene.
Single-stranded DNA-binding protein 2 is a protein that in humans is encoded by the SSBP2 gene.
AF4/FMR2 family member 3 is a protein that in humans is encoded by the AFF3 gene.
Protein ENL is a protein that in humans is encoded by the MLLT1 gene.
Retinoblastoma-binding protein 5 is a protein that in humans is encoded by the RBBP5 gene.
Myeloid/lymphoid or mixed-lineage leukemia 4, also known as MLL4, is a human gene.
Activating signal cointegrator 1 complex subunit 3 is a protein that in humans is encoded by the ASCC3 gene.
L-asparaginase is an enzyme that in humans is encoded by the ASRGL1 gene.
Ten-eleven translocation methylcytosine dioxygenase 1 (TET1) is a member of the TET family of enzymes, in humans it is encoded by the TET1 gene. Its function, regulation, and utilizable pathways remain a matter of current research while it seems to be involved in DNA demethylation and therefore gene regulation.
H3K4me1 is an epigenetic modification to the DNA packaging protein Histone H3. It is a mark that indicates the mono-methylation at the 4th lysine residue of the histone H3 protein and often associated with gene enhancers.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.