GABPB2

GABPB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AWC
Identifiers
Aliases	GABPB1 , BABPB2, E4TF1, E4TF1-47, E4TF1-53, E4TF1B, GABPB, GABPB2, NRF2B1, NRF2B2, GABPB-1, GA binding protein transcription factor beta subunit 1, GA binding protein transcription factor subunit beta 1
External IDs	OMIM: 600610 MGI: 95611 HomoloGene: 7723 GeneCards: GABPB1
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q21.2 Start 50,275,389 bp [1] End 50,355,408 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2 F1|2 61.76 cM Start 126,469,362 bp [2] End 126,518,257 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte bone marrow cells ganglionic eminence Achilles tendon stromal cell of endometrium lactiferous duct corpus epididymis monocyte rectum lymph node Top expressed in thymus ganglionic eminence spermatid cumulus cell medial ganglionic eminence secondary oocyte spermatocyte morula seminiferous tubule yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity protein heterodimerization activity protein binding Cellular component nucleus nucleoplasm cytoplasmic ribonucleoprotein granule Biological process regulation of transcription, DNA-templated mitochondrion organization positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2553 14391 Ensembl ENSG00000104064 ENSMUSG00000027361 UniProt Q06547 Q00420 RefSeq (mRNA) NM_002041 NM_005254 NM_016654 NM_016655 NM_181427 NM_001320910 NM_001320915 NM_001271467 NM_001271468 NM_001271469 NM_001271470 NM_001271492 NM_010249 NM_207669 NM_001355108 NM_001355109 RefSeq (protein) NP_001307839 NP_001307844 NP_002032 NP_005245 NP_057738 NP_057739 NP_852092 NP_057738.1 NP_001258396 NP_001258397 NP_001258398 NP_001258399 NP_001258421 NP_034379 NP_997552 NP_001342037 NP_001342038 NP_001393121 NP_001393122 NP_001393123 NP_001393124 NP_001393125 NP_001393126 NP_001393127 NP_001393128 NP_001393129 NP_001393130 NP_001393131 NP_001393132 NP_001393133 NP_001393134 NP_001393135 NP_001393136 NP_001393137 NP_001393138 NP_001393139 NP_001393140 NP_001393141 NP_001393142 NP_001393143 NP_001393144 NP_001393145 NP_001393146 NP_001393147 NP_001393148 NP_001393149 NP_001393150 NP_001393151 NP_001393152 NP_001393153 NP_001393154 NP_001393155 NP_001393156 Location (UCSC) Chr 15: 50.28 – 50.36 Mb Chr 2: 126.47 – 126.52 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

GA-binding protein subunit beta-1 is a protein that in humans is encoded by the GABPB1 gene. ^{[5] [6]}

This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000104064 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027361 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. de la Brousse FC, Birkenmeier EH, King DS, Rowe LB, McKnight SL (Nov 1994). "Molecular and genetic characterization of GABP beta". Genes Dev. 8 (15): 1853–65. doi: 10.1101/gad.8.15.1853 . PMID   7958862.
6. "Entrez Gene: GABPB2 GA binding protein transcription factor, beta subunit 2".

Further reading

• Sawada J, Goto M, Watanabe H, et al. (1995). "Regional mapping of two subunits of transcription factor E4TF1 to human chromosome". Jpn. J. Cancer Res. 86 (1): 10–2. doi:10.1111/j.1349-7006.1995.tb02981.x. PMC   5920589 . PMID   7737900.
• Gugneja S, Virbasius JV, Scarpulla RC (1995). "Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain". Mol. Cell. Biol. 15 (1): 102–11. doi:10.1128/MCB.15.1.102. PMC   231915 . PMID   7799916.
• Virbasius JV, Virbasius CA, Scarpulla RC (1993). "Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters". Genes Dev. 7 (3): 380–92. doi: 10.1101/gad.7.3.380 . PMID   8383622.
• Watanabe H, Sawada J, Yano K, et al. (1993). "cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs". Mol. Cell. Biol. 13 (3): 1385–91. doi:10.1128/MCB.13.3.1385. PMC   359448 . PMID   8441384.
• Gugneja S, Virbasius CM, Scarpulla RC (1996). "Nuclear respiratory factors 1 and 2 utilize similar glutamine-containing clusters of hydrophobic residues to activate transcription". Mol. Cell. Biol. 16 (10): 5708–16. doi:10.1128/mcb.16.10.5708. PMC   231571 . PMID   8816484.
• Sawa C, Goto M, Suzuki F, et al. (1997). "Functional domains of transcription factor hGABP beta1/E4TF1-53 required for nuclear localization and transcription activation". Nucleic Acids Res. 24 (24): 4954–61. doi:10.1093/nar/24.24.4954. PMC   146336 . PMID   9016666.
• Sowa Y, Shiio Y, Fujita T, et al. (1997). "Retinoblastoma binding factor 1 site in the core promoter region of the human RB gene is activated by hGABP/E4TF1". Cancer Res. 57 (15): 3145–8. PMID   9242441.
• Batchelor AH, Piper DE, de la Brousse FC, et al. (1998). "The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA". Science. 279 (5353): 1037–41. Bibcode:1998Sci...279.1037B. doi:10.1126/science.279.5353.1037. PMID   9461436.
• Suzuki F, Goto M, Sawa C, et al. (1998). "Functional interactions of transcription factor human GA-binding protein subunits". J. Biol. Chem. 273 (45): 29302–8. doi: 10.1074/jbc.273.45.29302 . PMID   9792629.
• Sawada J, Simizu N, Suzuki F, et al. (2000). "Synergistic transcriptional activation by hGABP and select members of the activation transcription factor/cAMP response element-binding protein family". J. Biol. Chem. 274 (50): 35475–82. doi: 10.1074/jbc.274.50.35475 . PMID   10585419.
• Vogel JL, Kristie TM (2000). "The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP". EMBO J. 19 (4): 683–90. doi:10.1093/emboj/19.4.683. PMC   305606 . PMID   10675337.
• Sawa C, Yoshikawa T, Matsuda-Suzuki F, et al. (2002). "YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors". J. Biol. Chem. 277 (25): 22484–90. doi: 10.1074/jbc.M203060200 . PMID   11953439.
• Marie S, Race V, Nassogne MC, et al. (2002). "Mutation of a nuclear respiratory factor 2 binding site in the 5' untranslated region of the ADSL gene in three patients with adenylosuccinate lyase deficiency". Am. J. Hum. Genet. 71 (1): 14–21. doi:10.1086/341036. PMC   384970 . PMID   12016589.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Jeong BC, Kim MY, Lee JH, et al. (2006). "Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor". FEBS Lett. 580 (2): 669–76. doi:10.1016/j.febslet.2005.12.086. PMID   16412436. S2CID   35468847.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.

External links

• GABPB2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt : Q00420 (Mouse GA-binding protein subunit beta-1) at the PDBe-KB .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.