DTX2

DTX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1V87
Identifiers
Aliases	DTX2 , RNF58, deltex 2, E3 ubiquitin ligase, deltex E3 ubiquitin ligase 2
External IDs	OMIM: 613141 MGI: 1921448 HomoloGene: 56904 GeneCards: DTX2
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q11.23 Start 76,461,676 bp [1] End 76,505,995 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 G2 Start 136,023,654 bp [2] End 136,061,726 bp [2]
RNA expression pattern Bgee Top expressed in sural nerve esophagus minor salivary gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding GO:0001948 protein binding metal ion binding transferase activity Cellular component cytoplasm nuclear membrane nucleus nucleoplasm Biological process Notch signaling pathway protein ubiquitination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	113878	74198
Ensembl	ENSG00000282379 ENSG00000091073	ENSMUSG00000004947
UniProt	Q86UW9	Q8R3P2
RefSeq (mRNA)	NM_001102594 NM_001102595 NM_001102596 NM_020892	NM_001256096 NM_001256097 NM_001256098 NM_023742
RefSeq (protein)	NP_001096064 NP_001096065 NP_001096066 NP_065943	NP_001243025 NP_001243026 NP_001243027 NP_076231
Location (UCSC)	Chr 7: 76.46 – 76.51 Mb	Chr 5: 136.02 – 136.06 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Protein deltex-2 also known as E3 ubiquitin-protein ligase DTX2 is an enzyme that in humans is encoded by the DTX2 gene. ^[5]

DTX2 functions as a ubiquitin E3 ligase in conjunction with the E2 enzyme UBCH5A. ^[6]

References

1. ENSG00000091073 GRCh38: Ensembl release 89: ENSG00000282379, ENSG00000091073 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000004947 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: DTX2 deltex homolog 2 (Drosophila)".
6. Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA (2003). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". J. Biol. Chem. 278 (24): 21930–7. doi: 10.1074/jbc.M301157200 . PMID   12670957.

Further reading

• Matsuno K, Diederich RJ, Go MJ, et al. (1995). "Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats". Development. 121 (8): 2633–44. doi:10.1242/dev.121.8.2633. PMID   7671825.
• Kishi N, Tang Z, Maeda Y, et al. (2001). "Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis". Int. J. Dev. Neurosci. 19 (1): 21–35. doi:10.1016/S0736-5748(00)00071-X. PMID   11226752. S2CID   21859491.
• Yamamoto N, Yamamoto S, Inagaki F, et al. (2002). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor". J. Biol. Chem. 276 (48): 45031–40. doi: 10.1074/jbc.M105245200 . PMID   11564735.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi: 10.1074/mcp.M500021-MCP200 . PMID   15778465.
• Hiller M, Huse K, Szafranski K, et al. (2007). "Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing". Am. J. Hum. Genet. 78 (2): 291–302. doi:10.1086/500151. PMC   1380236 . PMID   16400609.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.
• Yi Z, Yi T, Wu Z (2007). "cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos". DNA Seq. 17 (3): 175–80. doi:10.1080/10425170600857616. PMID   17286044. S2CID   26424595.

External links

• DTX2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.