NFX1

NFX1
Identifiers
Aliases	NFX1 , NFX2, TEG-42, Tex42, nuclear transcription factor, X-box binding 1
External IDs	OMIM: 603255 MGI: 1921414 HomoloGene: 1875 GeneCards: NFX1
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9p13.3 Start 33,290,512 bp [1] End 33,371,157 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4 A5|4 20.72 cM Start 40,970,906 bp [2] End 41,025,993 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in caput epididymis corpus epididymis endothelial cell right ventricle cavity of mouth biceps brachii gastrocnemius muscle human penis seminal vesicula amniotic fluid Top expressed in cumulus cell primitive streak seminal vesicula dermis hair follicle superior frontal gyrus aortic valve abdominal wall cerebellar cortex pituitary gland More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific zinc ion binding ligase activity RNA polymerase II transcription regulatory region sequence-specific DNA binding metal ion binding nucleic acid binding RNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transferase activity ubiquitin protein ligase activity Cellular component plasma membrane nucleolus nucleus cytosol Biological process inflammatory response viral process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II negative regulation of MHC class II biosynthetic process transcription, DNA-templated protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4799 74164 Ensembl ENSG00000086102 ENSMUSG00000028423 UniProt Q12986 B1AY10 RefSeq (mRNA) NM_002504 NM_147133 NM_147134 NM_001318758 NM_001290448 NM_001290449 NM_023739 RefSeq (protein) NP_001305687 NP_002495 NP_667345 NP_001277377 NP_001277378 NP_076228 Location (UCSC) Chr 9: 33.29 – 33.37 Mb Chr 4: 40.97 – 41.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcriptional repressor NF-X1 is a protein that in humans is encoded by the NFX1 gene. ^{[5] [6] [7]}

MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-γ. Three alternative splice variants, each of which encodes a different isoform, have been identified. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000086102 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028423 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Song Z, Krishna S, Thanos D, Strominger JL, Ono SJ (Dec 1994). "A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor". J Exp Med. 180 (5): 1763–74. doi:10.1084/jem.180.5.1763. PMC   2191754 . PMID   7964459.
6. Hume CR, Lee JS (Jan 1990). "Congenital immunodeficiencies associated with absence of HLA class II antigens on lymphocytes result from distinct mutations in trans-acting factors". Hum Immunol. 26 (4): 288–309. doi:10.1016/0198-8859(89)90007-4. PMID   2511169.
7. Arlotta P, Miyazaki D, Copeland NG, Gilbert DJ, Jenkins NA, Ono SJ (June 2002). "Murine NFX.1: isolation and characterization of its messenger RNA, mapping of its chromosomal location and assessment of its developmental expression". Immunology. 106 (2): 173–81. doi:10.1046/j.1365-2567.2002.01416.x. PMC   1782705 . PMID   12047746.
8. "Entrez Gene: NFX1 nuclear transcription factor, X-box binding 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Lorick KL, Jensen JP, Fang S, et al. (1999). "RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11364–9. Bibcode:1999PNAS...9611364L. doi: 10.1073/pnas.96.20.11364 . PMC   18039 . PMID   10500182.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Saito K, Fujiwara T, Katahira J, et al. (2004). "TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD". Biochem. Biophys. Res. Commun. 321 (2): 291–7. doi:10.1016/j.bbrc.2004.06.140. PMID   15358174.
• Gewin L, Myers H, Kiyono T, Galloway DA (2004). "Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex". Genes Dev. 18 (18): 2269–82. doi:10.1101/gad.1214704. PMC   517520 . PMID   15371341.
• Katzenellenbogen RA, Egelkrout EM, Vliet-Gregg P, et al. (2007). "NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells". J. Virol. 81 (8): 3786–96. doi:10.1128/JVI.02007-06. PMC   1866132 . PMID   17267499.

External links

• NFX1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)