PROX1

Last updated
PROX1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PROX1 , prospero homeobox 1
External IDs OMIM: 601546 MGI: 97772 HomoloGene: 2069 GeneCards: PROX1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001270616
NM_002763

NM_008937
NM_001360827

RefSeq (protein)

NP_001257545
NP_002754

NP_032963
NP_001347756

Location (UCSC) Chr 1: 213.98 – 214.04 Mb Chr 1: 189.85 – 189.9 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene. [5] [6] The Prox1 gene is critical for the development of multiple tissues. Prox1 activity is necessary and sufficient to specify a lymphatic endothelial cell fate in endothelial progenitors located in the embryonic veins. [7]

Contents

Interactions

PROX1 has been shown to interact with EP300. [8]

Production

PROX1 is produced primarily in the dentate gyrus in the mouse, and in the dentate gyrus and white matter in humans. Gene expression data for mouse, human and macaque from the Allen Brain Atlases can be found here.

Clinical significance

PROX1 is used as a marker for lymphatic endothelium in biopsy samples.

Homologous gene

PROX2

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000117707 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000010175 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Zinovieva RD, Duncan MK, Johnson TR, Torres R, Polymeropoulos MH, Tomarev SI (Dec 1996). "Structure and chromosomal localization of the human homeobox gene Prox 1". Genomics. 35 (3): 517–22. doi:10.1006/geno.1996.0392. PMID   8812486.
  6. "Entrez Gene: PROX1 prospero-related homeobox 1".
  7. Harvey, Natasha L (October 2005). "Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity". Nature Genetics. 37 (10): 1072–1081. doi:10.1038/ng1642. PMID   16170315. S2CID   25103068.
  8. Chen, Qin; Dowhan Dennis H; Liang Dongcai; Moore David D; Overbeek Paul A (Jul 2002). "CREB-binding protein/p300 co-activation of crystallin gene expression". J. Biol. Chem. 277 (27). United States: 24081–9. doi: 10.1074/jbc.M201821200 . ISSN   0021-9258. PMID   11943779.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.