Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene. [5] [6] The Prox1 gene is critical for the development of multiple tissues. Prox1 activity is necessary and sufficient to specify a lymphatic endothelial cell fate in endothelial progenitors located in the embryonic veins. [7]
PROX1 is produced primarily in the dentate gyrus in the mouse, and in the dentate gyrus and white matter in humans. Gene expression data for mouse, human and macaque from the Allen Brain Atlases can be found here.
PROX1 is used as a marker for lymphatic endothelium in biopsy samples.
Forkhead box protein C2 (FOXC2) also known as forkhead-related protein FKHL14 (FKHL14), transcription factor FKH-14, or mesenchyme fork head protein 1 (MFH1) is a protein that in humans is encoded by the FOXC2 gene. FOXC2 is a member of the fork head box (FOX) family of transcription factors.
Homeobox protein Hox-A5 is a protein that in humans is encoded by the HOXA5 gene.
Hematopoietically-expressed homeobox protein HHEX is a protein that in humans is encoded by the HHEX gene and also known as Proline Rich Homeodomain protein PRH.
Insulin gene enhancer protein ISL-1 is a protein that in humans is encoded by the ISL1 gene.
Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene.
Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene.
Homeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene.
Zinc finger homeobox protein 3 is a protein that in humans is encoded by the ZFHX3 gene.
Homeobox protein Hox-C6 is a protein that in humans is encoded by the HOXC6 gene. Hox-C6 expression is highest in the fallopian tube and ovary. HoxC6 has been highly expressed in many types of cancers including prostate, breast, and esophageal squamous cell cancer.
T-cell leukemia homeobox protein 3 is a protein that in humans is encoded by the TLX3 gene.
Transcription factor SOX-18 is a protein that in humans is encoded by the SOX18 gene.
Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1), also known as extracellular link domain containing 1 (XLKD1) is a Link domain-containing hyaladherin, a protein capable of binding to hyaluronic acid (HA), homologous to CD44, the main HA receptor. In humans it is encoded by the LYVE1 gene.
Homeobox protein MOX-2 is a protein that in humans is encoded by the MEOX2 gene.
Homeobox protein Hox-D1 is a protein that in humans is encoded by the HOXD1 gene.
Visual system homeobox 1 is a protein that in humans is encoded by the VSX1 gene.
Homeobox protein Hox-C10 is a protein that in humans is encoded by the HOXC10 gene.
Homeobox protein Hox-C11 is a protein that in humans is encoded by the HOXC11 gene.
Paired mesoderm homeobox protein 2 is a protein that in humans is encoded by the PRRX2 gene.
Homeobox protein Hox-A2 is a protein that in humans is encoded by the HOXA2 gene.
Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.